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ALTER TABLE table_name DISABLE KEYS
-----DO STUFF HERE------
ALTER TABLE table_name ENABLE KEYS
ALTER TABLE ... DISABLE KEYS tells MySQL to stop updating non-unique indexes.
ALTER TABLE ... ENABLE KEYS then should be used to re-create missing indexes.
MySQL does this with a special algorithm that is much faster than inserting keys one by one, so disabling keys before performing bulk insert operations should give a considerable speedup.
Using ALTER TABLE ... DISABLE KEYS requires the INDEX privilege in addition to the privileges mentioned earlier.
While the non-unique indexes are disabled, they are ignored for statements such as SELECT and EXPLAIN that otherwise would use them.